Alexander Hleb has joined Arsenal's growing injury list, which also includes Tomas Rosicky, William Gallas, Jens Lehmann and Emmanuel Eboue.
Hleb has a knee injury, but on a more positive note the Gunners can call on Philippe Senderos after a hip problem.
Derby are set to be unchanged from the team that notched their first win of the campaign against Newcastle.
Kenny Miler's hamstring held up to the test, and while Darren Moore and Giles Barnes are fit, the match is too soon.
Arsenal will look to strengthen their position at the top of the table as they face a Derby side fresh from their first win of the season.
Though they were always going to challenge for a UEFA Champions League spot, The Gunners could be considered one of the Premier League's surprise packages for the way they have flourished since Thierry Henry's departure in the summer.
They are unbeaten in all competitions this season and appear to be going from strength to strength after following up their victory over Tottenham with an impressive 3-0 win against Sevilla in midweek.
The Mighty Arsenal's verdict:
We reckon this will be a comfortbale win for Arsenal but we need to watch out for Derby who could take advantage of a tired Arsenal side.
Prediction: Arsenal 3-1 Derby